Hemodialysis-dependent: 0.5 mg/kg IV q2weeks for 12 weeks; not to exceed 100 mg/dose, Non-dialysis dependent or peritoneal-dependent (on erythropoietin): 0.5 mg/kg IV q4weeks for 12 weeks; not to exceed 100 mg/dose, sodium sulfate/?magnesium sulfate/potassium chloride, sodium sulfate/potassium sulfate/magnesium sulfate, Serious hypersensitivity reactions reported, including anaphylactic-type reactions, some of which have been life-threatening and fatal, Patients may present with shock, clinically significant hypotension, loss of consciousness, and/or collapse, If hypersensitivity reactions or signs of intolerance occur during administration, stop infusion immediately, Monitor patients for signs and symptoms of hypersensitivity during and after administration for at least 30 minutes and until clinically stable following completion of the infusion, Animal reproduction studies of iron sucrose administered to rats and rabbits during period of organogenesis at elemental iron doses equivalent to maximum recommended human dose based on body surface area revealed no evidence of harm to the fetus; adverse outcomes in pregnancy occur regardless of health of mother or use of medications, Iron deficiency anemia during pregnancy should be treated; untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia; adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight, HD-dependent and non-dialysis-dependent CKD: Dilute with up to 100 mL of 0.9% NaCl, PD-dependent CKD: Dilute with up to 250 mL of 0.9% NaCl, Undiluted: Administer by slow IV injection over 2-5 min, Diluted solutions: Administer IV over 15 min, Undiluted: Administer by slow IV injection over 5 minutes, Diluted solutions: Administer IV over 5-60 minutes, Store in original carton at 20-25C (68-77 F); excursions permitted to 15- 30C (59-86F), Syringe: Store at room temperature (25C) or under refrigeration (4C) for up to 7 days, IV infusion: Store at room temperature (25C) for up to 7 days. feasible, Maximum total cumulative iron sucrose dose administered in 14 days is 1000 mg elemental iron. In a randomized, open-label, dose-ranging trial for iron maintenance treatment with Venofer in pediatric patients with CKD on stable erythropoietin therapy [see Clinical Studies ( 14.7)], at least one adverse reaction was experienced by 57% (27/47) of the patients receiving Venofer 0.5 mg/kg, 53% (25/47) of the patients receiving Venofer 1 mg . Your list will be saved and can be edited at any time. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Applies only to oral form of both agents. Adult Dosage and Administration: The recommended dosage of Ferrlecit for the repletion treatment of iron deficiency in hemodialysis patients is 10 mL of Ferrlecit (125 mg of elemental iron). 2010; 193(9):525-32. Serious - Use Alternative (1)iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. FOR PATIENTS WEIGHING 50 kg OR MORE: Administer 1000 mg of Monoferric by intravenous infusion 20 minutes as a single dose 1. Use Caution/Monitor. Minor (2)calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Do Not Copy, Distribute or otherwise Disseminate without express permission. J Lab Clin Med. Minor/Significance Unknown.iron sucrose increases levels of calcium citrate by enhancing GI absorption. Manage and view all your plans together even plans in different states. Administer on 5 different occasions over a 14 day period. Use alternatives if available. Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf. Koch TA, Myers J, Goodnough LT. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Avoid or Use Alternate Drug. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Assessing new treatment options, Intravenous iron-dextran: therapeutic and experimental possibilities. This site complies with the HONcode standard for trust- worthy health information: verify here. SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. Estimates the iron deficit in preparation for iron replacement based on patient weight and haemoglobin. Each mL contains 20 mg of elemental iron. Avoid or Use Alternate Drug. This site contains information for licensed healthcare professionals in the United States. Corrected Calcium. Use Caution/Monitor. In less advanced cases of iron deficiency, increases in dietary intake of iron may be sufficient. Mean change in Hgb from baseline to Week 5 2,5 Applies only to oral form of both agents. 4) Gozzard D. (2011) When is high-dose intravenous iron repletion needed? restrictions. Avoid or Use Alternate Drug. The Ganzoni equation is: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron - carboxymaltose); The dosage of Venofer is expressed in mg of elemental iron. Applies only to oral form of both agents. calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Transferrin saturation (TSAT) values increase rapidly after intravenous administration of iron sucrose; do not perform serum iron measurements for at least 48 hours after intravenous dosing. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. Either decreases levels of the other by inhibition of GI absorption. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. Baloxavir may bind to polyvalent cations resulting in decreased absorption. The above information is provided for general Avoid or Use Alternate Drug. Parenteral iron supplementation. Applies only to oral form of both agents. ------------------------------------------------------------------------- Iron Dextran Complex [ Infed ] Elemental iron: 50 mg of elemental iron per mL [2 mL] [package insert] BOXED WARNING: WARNING: RISK FOR ANAPHYLACTIC-TYPE REACTIONS Anaphylactic-type reactions, including fatalities, have followed the parenteral administration of iron dextran injection. Use Caution/Monitor. For liquid medications, also enter the value of the Medicine Concentration and choose . Deferoxamine chelates iron. Applies only to oral form of both agents. The iron deficit estimation is based on the Ganzoni formula: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. Allow at least 30 minutes between administration of Feraheme and administration of other medications that could potentially cause serious hypersensitivity reactions and/or hypotension, such as chemotherapeutic agents or monoclonal antibodies. 0.5 mg/kg/min (0.005 mL/kg/min) Maximum infusion rate (if tolerated) Increase to 8 mg/kg/min (0.08 mL/kg/min) Monitor the patient's vital signs throughout the infusion. The initial hemoglobin rise is more rapid with parenteral iron but on the long term (12 weeks), both therapies reach similar levels of hemoglobin. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Use Caution/Monitor. The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Monitor Closely (1)deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. trientine, iron sucrose. The dosing for iron replacement treatment in pediatric patients with Peritoneal or Hemodialysis-Dependent - CKD or Non-Dialysis Dependent CKD have not been established. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Use Caution/Monitor. Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. iron sucrose decreases levels of doxycycline by inhibition of GI absorption. informational and educational purposes only. IMPORTANT SAFETY INFORMATION DOSAGE AND ADMINISTRATION Pediatric Patients (2 Years of Age and Older) Intravenous iron-dextran: therapeutic and experimental possibilities. Minor (2)calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. Get in touch with MDApp by using the following contact details: 2017 - 2023 MDApp. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: vitamin products, other iron-containing products. Drug class: Iron products. iron sucrose increases levels of calcium citrate by enhancing GI absorption. Steps on how to print your input & results: 1. Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. Individual plans may vary Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes, or sooner, it is recommended that a period of an hour or longer elapse before the remainder of the initial therapeutic dose is given. Minor/Significance Unknown. Applies only to oral form of both agents. Baloxavir may bind to polyvalent cations resulting in decreased absorption. The prevention and treatment of iron deficiency is a major public health goal, especially in women, children, and individuals in low-income countries. Minor/Significance Unknown. These can be input in g/dL, g/L or mmol/L. calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. INDICATIONS AND USAGE: Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Applies only to oral form of both agents. Medicinal forms 1995 Mar-Apr;11(2):163-8. Medscape Education, Improving Quality of Care in Patients With Iron Deficiency Anemia and Inflammatory Bowel Disease, 2010feosol-carbonyl-fe-icar-c-carbonyl-iron-342171Drugs, encoded search term (iron sucrose (Venofer)) and iron sucrose (Venofer), Use of High-Dose Iron in Dialysis in US Tracks PIVOTAL Trial, FDA Watch List Adds Drugs With Anaphylaxis, Herpes, Fetal Death Risk, Dialysis Industry Mergers: Profits Rise as Patient Outcomes Worsen, Hematology-Oncology Guidelines: 2017 Midyear Review. Ren Fail. Avoid or Use Alternate Drug. Iron sucrose (Venofer) 100 mg/5 mL vial 200 - 300 mg given every 3-7 days 300 mg doses are given over 90 minutes 500 mg/dose. Give each dose as 750mg for a total cumulative dose not to exceed1500mg of ironper course. Calculates iron deficit for dosing iron. US residents can call their local poison control center at 1-800-222-1222. Generic name: IRON SUCROSE 20mg in 1mL The dosage is expressed in terms of mg of elemental iron, with each mL of Feraheme containing 30 mg of elemental iron. Most Minor/Significance Unknown.iron sucrose increases levels of calcium gluconate by enhancing GI absorption. Intravenous therapy is preferred for urgent intervention and when oral iron cannot be absorbed or the patient suffers from chronic renal impairment. Manufacturer advises for slow intravenous injection ( Venofer ), give undiluted at a rate of 1 mL/minute; do not exceed 10 mL (200 mg iron) per injection. Minor/Significance Unknown. Minor/Significance Unknown. Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. The primary endpoint was the proportion of patients with . Give each dose as 750 mg for a total cumulative dose not to exceed 1500 mg of iron per course. The dosage of Venofer is expressed in mg of elemental iron. 4. After total replacement dose completed, need for ongoing IV doses should be re-assessed monthly. IDA diagnosis is based on full blood examination and on the serum ferritin level. The dosage of Venofer is expressed in mg of elemental iron. 1 Dosing for patients who weigh less than 50 kg Your dosage and length of treatment are based on your medical condition, age, and response to treatment. Consult your doctor before breast-feeding. Avoid or Use Alternate Drug. In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . Applies only to oral form of both agents. iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. *Administer early during the dialysis session. Replacement of iron stores found in hemoglobin, myoglobin, and enzymes; works to transport oxygen via hemoglobin, Do not mix with other medications or add to parenteral nutrition solutions for IV infusion, Do not dilute to concentrations below 1 mg/mL, Add dose to 0.9% NaCl infusion bags (PVC or non-PVC); final concentrations range is 1-2 mg of elemental iron/mL, Visually inspect for particulate matter and discoloration prior to infusion, Stable for 7 days at controlled room temperature (25C). Formula for calculating the required dose of iron sucrose 1. . Observed Hb = the patients current hemoglobin in g/dl. Intravenous Injection - PRIOR TO THE FIRST INTRAVENOUS INFeD THERAPEUTIC DOSE, ADMINISTER AN INTRAVENOUS TEST DOSE OF 0.5 ML. Dosing: (a) Divide calculated total cumulate dose . Anemia. Avoid or Use Alternate Drug. Venofer may cause clinically significant hypotension. Congenital Pulmonary Airway Malformation Volume Ratio (CVR) Calculator -. Monitor Closely (1)omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Max Dose. INFED- iron dextran injection [Package insert], Hemoglobin iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) Note: Hbg (current hemoglobin level) units: (g/dL) Alternatively: Volume of product required (mL) = [weight (kg) x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. Venofer (iron sucrose) dose calculator | Calculosaurus.com Clinical calculators for obstetrics and gynaecology VTE risk assessment Calculator menu Venofer dose calculator Iron sucrose Not what you were looking for? Feraheme, when added to intravenous infusion bags containing either 0.9% Sodium Chloride Injection, USP (normal saline), or 5% Dextrose Injection, USP, at concentrations of 2-8 mg elemental iron per mL, should be used immediately but may be stored at controlled room temperature (25C 2C) for up to 4 hours or refrigerated (2-8 C) for up to 48 hours. Excessive therapy with parenteral iron can lead to excess storage of iron with the possibility of iatrogenic hemosiderosis. Use Caution/Monitor. Applies only to oral form of both agents. Hollands J, Foote E, Rodriguez A. commonly, these are generic drugs. World J Gastroenterol; 16(22): 27202725. The original formula employs the weight in kg but users can input it in lbs and it gets transformed. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Minor (1)iron sucrose decreases levels of manganese by inhibition of GI absorption. Initial infusion rate. Intravenous iron sucrose: establishing a safe dose. Applies only to oral form of both agents. an automated flowchart approach. Applies only to oral form of both agents. Kumpf VJ. 4. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Iron Dextran Dosing Calculator (iron deficit). Am J HealthSyst Pharm 2006;63:731735. Available for Android and iOS devices. The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. DOSAGE AND ADMINISTRATION: Venofer must only be administered intravenously either by slow injection or by infusion. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Applies only to oral form of both agents. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. Minor/Significance Unknown. Applies only to oral form of both agents. Applies only to oral form of both agents. Challenges in the treatment of iron deficiency include finding and addressing the underlying cause and the selection of an iron replacement product that meets the needs of the patient. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. A: Generally acceptable. official version of the modified score here. Applies only to oral form of both agents. No data are available regarding overdosage of Venofer in humans. Minor/Significance Unknown. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling [16.2].) Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. STORAGE: Consult the product instructions and your pharmacist for storage details. Equations used: 1] Calculation of the Total Iron Deficit: Total iron deficit [mg] = body weight [kg] x (target Hb-actual Hb) [g/dl] x 2.4 + depot iron [mg]. Pain, swelling, or redness at the injection site may occur. Applies only to oral form of both agents. Applies only to oral form of both agents. Discard unused portion. Applies only to oral form of both agents. Adding plans allows you to compare formulary status to other drugs in the same class. If either is present, do not use the liquid. Applies only to oral form of both agents. Iron supplements, whether administered orally, intramuscular or intravenous, are used to replenish body stores and correct anemia. Iron Sucrose [ Venofer ] Elemental iron: 20 mg/mL (2.5 mL, 5 mL, 10 mL) Solution, Intravenous [preservative free]: [package insert] INDICATIONS: Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with chronic kidney disease (CKD). Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. By clicking send, you acknowledge that you have permission to email the recipient with this information. Parenteral iron dextran therapy. UpToDate. Applies only to oral form of both agents. Venofer is given as an infusion into a vein. FERAHEME Dosing & Administration - Feraheme FERAHEME has flexible dosing for your patients FERAHEME flexible scheduling gives your patients the freedom to receive the iron they need as early as 3 days apart 1 FLEXIBLE DILUTION OPTIONS 1 Dilute full contents of vial (17 mL) in 50 mL to 200 mL of: 0.9% NaCl, or 5% dextrose STORAGE 1 cybersecurity insurance trends, parkside 4 in 1 multi detector manual, cali auto auction pomona inventory,